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Inhalations of nitrogen monoxide (NO) is a therapy, which is particularly valuable in resuscitation of neonates and cardiac surgery. It improves oxygen saturation in case of acute pulmonary injuries without forming undesirable vasodilation.
The product is intended for treatment of neonates whose gestational age is 34 or more weeks and who have hypoxic respiratory failure related to clinical or echocardiographic symptoms of pulmonary hypertension. The use of this substance is part of the treatment of perioperative and postoperative hypertension in neonates, babies, toddlers, children, adolescents (0–17 years of age) and adults during heart surgeries in order to selectively reduce blood pressure in the lung arteries and to improve the function and oxygenation of the right ventricle.
Medical nitric oxide (iNO) is a pulmonary vessels vasodilator, which is important in regulating vascular muscle tone.
Nitric oxide gas effects pulmonary vessels only by restoring their normal function. Nitric oxide therapy is applied in the following cases:
- Respiratory failure of neonates (chronic pulmonary hypertension, pneumonia, neonatal respiratory distress syndrome of neonates).
- After surgeries of congenital heart pathologies with pulmonary hypertension or risk of hypertensive crisis.
- Adult respiratory distress syndrome.
- After pulmonary thromboendarterectomy performed in the cases of chronic pulmonary thromboembolism.
- Lung transplantation.
- In cases of heart transplantation with pulmonary hypertension, because of which a risk of right ventricular failure develops.
- Prevention of right ventricular failure and treatment of pulmonary hypertension in the patients suffering from heart failure with left ventricular assist device.
- The patients with heart valve pathologies, suffering from severe pulmonary hypertension, and exposed to the risk of right ventricular failure.
